Droplet-based Multi-omics
SeekOne DD single-cell multi-omics. Profile RNA together with chromatin accessibility or DNA methylation from the same cell, run as a full sequencing service by Xpress Genomics.
SeekOne DD single-cell multi-omics. Profile RNA together with chromatin accessibility or DNA methylation from the same cell, run as a full sequencing service by Xpress Genomics.
Single-cell multi-omics measures more than one type of molecule in the same cell. The SeekOne DD Digital Droplet System is a high-throughput, automated platform that uses microfluidic water-in-oil droplets to separate and barcode cells or nuclei one at a time. This lets us capture RNA together with a second readout such as chromatin accessibility or DNA methylation from each cell.
Xpress Genomics offers this technology as a full sequencing service. You send us your samples and we handle cell preparation, library construction, sequencing and data analysis. As a SeekGene distributor, we can also supply the SeekOne DD reagents and instrument if you prefer to run the workflow in your own lab.
The SeekOne DD Single-Cell Multiome ATAC + RNA assay measures open chromatin (ATAC) and the transcriptome (RNA) in the same nucleus. This makes it possible to link gene regulation to gene expression cell by cell. A random-primed RNA strategy gives near full-length coverage and detects non-polyadenylated transcripts, and a dual-index library design reduces index hopping.
This is one of our two main multi-omics services. We run the full workflow: nuclei preparation, Tn5 transposition, droplet partitioning, paired library preparation, sequencing, and joint ATAC and RNA analysis with SeekArc™ Tools.
The SeekOne DD Single-Cell Multiome Methylation + RNA assay measures genome-wide DNA methylation (5mC) at single-base resolution together with the transcriptome of the same cell. It can also be extended to immune repertoire (V(D)J) and copy-number variation.
This is our second main multi-omics service. It works at high throughput with nuclei or whole cells from fresh or frozen tissue and blood. Xpress Genomics handles fixation and nucleosome depletion, droplet barcoding, paired library construction, sequencing, and joint methylation and RNA analysis with SeekSoul Methyl Tools.
You send us cells, nuclei or tissue. We take care of dissociation where the assay needs it, and quality control of the input material.
Single cells or nuclei are partitioned and barcoded on the SeekOne DD Digital Droplet System, which tags both readouts inside the same droplet.
Our team builds the paired libraries for expression plus ATAC or methylation using validated SeekOne DD chemistry.
We sequence the libraries in-house on our own instruments, which keeps larger multi-omics studies affordable.
We process the data with SeekGene’s SeekArc and SeekSoul™ pipelines on our own servers and return the results to you.
The same droplet platform runs a wide range of single-cell and spatial assays. If you need a transcriptome-only readout or a full multi-omic profile, we can set up the right workflow. As a SeekGene distributor, we can also supply the reagents and instruments for labs that run these assays themselves.
Random-primed single-cell RNA-seq with uniform, near full-length transcript coverage and broad RNA compatibility, including non-polyadenylated transcripts.
High-throughput single-cell 3′ RNA profiling for precise cell-state and gene-expression analysis across tens of thousands of cells.
Paired gene-expression and immune-repertoire (TCR/BCR) profiling for clonotype tracking and immune-diversity analysis.
Probe-based single-nucleus RNA-seq for FFPE and briefly fixed cells and nuclei, with high specificity and sensitivity from difficult samples.
True single-nucleus spatial transcriptomics that links gene expression with spatial context in the same tissue slice.
As a SeekGene distributor, Xpress Genomics can also supply SeekOne DD reagent kits and the Digital Droplet System for labs that prefer to run single-cell multi-omics themselves.
Feel free to contact us to find out how we can help with your current project. You can also submit a request for a quote.
Contact UsXpress Genomics was founded in
2022 in Stockholm (Sweden) based on
our in-house technology for scalable
full-length single-cell RNA-seq.
Cancer Centrum Karolinska,
Visionsgatan 56, 171 64 Solna, Sweden
© Xpress Genomics, Stockholm, Sweden. 2025
